The latest guy in the ring is Highcharts uses either jQuery or MooTools for some common JavaScript tasks. In addition, Internet Explorer needs ExCanvas which emulates the Canvas element.

For some simple code like this:

[codesyntax lang="javascript"]
var chart1 = new Highcharts.Chart({
chart: {
renderTo: ‘chart-container-1′,
defaultSeriesType: ‘bar’
},
title: {
text: ‘Fruit Consumption’
},
xAxis: {
categories: ['Apples', 'Bananas', 'Oranges]
},
yAxis: {
title: {
text: ‘Fruit eaten’
}
},
series: [{
name: 'Jane',
data: [1, 0, 4]
}, {
name: ‘John’,
data: [5, 7, 3]
}]
});
[/codesyntax]

You can get nice charts like this:

Be sure to check out the demo gallery.